The Best Friend Bones Original knotted bones are made of 100% natural premium cowhide. Due to their size and texture (hard bite), these bones are an excellent choice for medium-sized and large dogs with a strong bite force. Since cowhide is the only ingredient, the product is also suitable for dogs with allergies. Regular use of chewing products helps maintain tooth and gum health and prevent bad breath. Chewing products also make for excellent entertainment and effectively invigorate your dog during dull moments while stimulating the natural chewing instinct.